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目的:了解左氧氟沙星致不良反应(ADR)的特点及规律,为临床合理用药提供参考。方法:从CNKI数据库和万方数据库中检索2000-2013年关于左氧氟沙星致ADR的个案报道,就不良反应相关情况进行统计和分析。结果:161例患者中,ADR发生最早为用药后l min,多数发生在用药1 h以内,占总例数的61.5%;患者日剂量主要集中在0.2~0.4 g,占87.6%;ADR发生率静脉滴注途径(80.7%)显著高于口服途径(19.3%);不良反应以中枢及外周神经系统损害、循环系统损害、全身性损害为主,占总例次的65.9%。结论:左氧氟沙星在临床使用时应重视中枢及外周神经系统损害及过敏性休克等ADR的发生,采取有效措施防范和应对。
Objective: To understand the characteristics and laws of levofloxacin-induced adverse reactions (ADRs) and to provide a reference for clinical rational drug use. Methods: From 2000 to 2013, CNKI database and Wanfang database were searched to report the cases of ADR caused by levofloxacin. The data of adverse reactions were collected and analyzed. Results: Among the 161 patients, ADR occurred at least 1 min after drug administration, most of which occurred within 1 h of medication, accounting for 61.5% of the total. The daily dose of ADR was mainly concentrated in 0.2-0.4 g (87.6%). The incidence of ADR The intravenous drip route (80.7%) was significantly higher than the oral route (19.3%). The adverse reactions were mainly central and peripheral nervous system damage, circulatory system damage and generalized injury, accounting for 65.9% of the total cases. Conclusion: Levofloxacin in clinical use should pay attention to the central and peripheral nervous system damage and the occurrence of ADR such as anaphylactic shock and take effective measures to prevent and respond.