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目的:探讨冻融胚胎卵裂球完整性对胚胎发育潜能的影响。方法:回顾性分析126个冻融胚胎移植周期,按照移植胚胎的卵裂球的完整性分为两组:无损伤组(所有移植胚胎均完整无损,n=78),部分损伤组(移植胚胎中至少含1个有卵裂球损伤的胚胎,n=48),比较两组临床妊娠率、种植率和流产率。结果:无损伤组临床妊娠率为37.18%(29/78),种植率23.72%(37/156),流产率3.45%(1/29)。部分损伤组临床妊娠率为33.33%(16/48),种植率13.85%(18/130),流产率12.50%(2/16),两组临床妊娠率和流产率比较,差异无统计学意义(P>0.05),种植率比较差异具有统计学意义(P<0.05)。结论:部分卵裂球损伤的冻融胚胎,其种植潜能降低,卵裂球完整性是影响临床结局的关键性因素。
Objective: To investigate the effect of the integrity of the frozen-thawed blastocysts on embryonic development potential. Methods: The 126 cycles of frozen-thawed embryo transfer were retrospectively analyzed. According to the integrity of the blastomeres of the embryos, the embryos were divided into two groups: intact (all intact, n = 78) Including at least one embryo with blastomere damage (n = 48). The clinical pregnancy rate, implantation rate and abortion rate were compared between the two groups. Results: The clinical pregnancy rate in non-injury group was 37.18% (29/78), the implantation rate was 23.72% (37/156) and the abortion rate was 3.45% (1/29). The clinical pregnancy rate was 33.33% (16/48) in partial injury group, the implantation rate was 13.85% (18/130) and the abortion rate was 12.50% (2/16). There was no significant difference in clinical pregnancy rate and abortion rate between the two groups (P> 0.05). The difference in implantation rate was statistically significant (P <0.05). Conclusion: Some blastomere-damaged frozen-thawed embryos have lower implantation potential and blastomere integrity as the key factors affecting the clinical outcome.