In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadi

• 作 者: Xiaoxiao Wen Yudong Zheng Jian
• 机 构: School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 1
• 出 处: 自然科学进展（英文版）
• 发表日期: 2015年3期
• 关键词: Bacterial cellulose Silver sulfadiazine Antibacterial activity Burn wound healin

Silver sulfadiazine (SSD) particles in homogeneous dispersion state were prepared by an ultrasonic method and then nano-and microparticles were separated using centrifugation. SSD particles with narrow size distribution were impregnated with bacterial cellulose (BC) to produce BC–SSD composite membrane used as b wound dressing. A scanning electron microscope (SEM) was used to examine the surface morphology of BC–SSD membranes. The incorporation of SSD in BC–SSD was confirmed by X-ray diffraction (XRD). Antimicrobial tests in vitro indicated that BC–SSD showed excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effects of BC–SSD on b wound healing were assessed by rat models. The comparative study confirmed that the wound treated with BC–SSD showed high healing rate. The bacteria count in BC–SSD group was far less than control group. Histological analysis showed that epithelialization progressed better in wound treated with BC–SSD. These values demonstrated that the BC–SSD composite membrane could be a promising wound dressing for b.