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探讨局限期小细胞肺癌(smallcelllungcancer,SCLC)患者化疗前后的记忆功能变化,对36例局限期SCLC患者在化疗前、后分别采用韦氏记忆量表(WMS)测评,比较化疗前后记忆力的变化。患者化疗前记忆商数MQ=94.20±9.63,化疗后MQ=92.71±8.20,化疗前后比较差异无统计学意义,t=1.462,P>0.05;在10分测验中,有3个分测验即图片回忆、再认和联想学习的量表分化疗后比化疗前降低(8.58±2.52vs9.38±2.37,7.63±2.33vs8.45±2.41,7.57±3.50vs8.50±3.31),差异均有统计学意义,P<0.05。本研究结果提示,化疗对SCLC患者的总体记忆力无显著损害,但化疗可能损害了患者记忆的某些成分如短时记忆。
To investigate the changes of memory function in patients with small cell lung cancer (SCLC) before and after chemotherapy. 36 cases of SCLC patients were evaluated by WMS before and after chemotherapy, and the changes of memory were compared before and after chemotherapy. Before chemotherapy, the number of memory quotient MQ = 94.20 ± 9.63, post-chemotherapy MQ = 92.71 ± 8.20, no significant difference before and after chemotherapy, t = 1.462, P> 0.05; Memorization, recognition and association learning scale after chemotherapy than before chemotherapy decreased (8.58 ± 2.52 vs 9.38 ± 2.37, 7.63 ± 2.33 vs 8.45 ± 2.41, 7.57 ± 3.50 vs 8.50 ± 3.31), the difference was statistically Significance, P <0.05. The results of this study suggest that chemotherapy does not significantly impair the overall memory of patients with SCLC, but chemotherapy may damage certain components of the patient’s memory such as short-term memory.