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目的探讨MTHFR C677T多态性及HCY与复发性流产的关系。方法纳入100例复发性流产患者为观察组,同时纳入100例正常妊娠史孕前检查妇女作为对照组,同时检测MTHFR基因C677T多态性及HCY浓度。结果本研究检测的100例复发性流产病例和100例正常妊娠史病例MTHFR基因型分布无特异性,但HCY浓度在两组间差异明显,且在TT型中,HCY浓度明显升高。结论可以把HCY检测作为复发性流产的一个重要监测指标。
Objective To investigate the relationship between MTHFR C677T polymorphism and HCY and recurrent spontaneous abortion. Methods One hundred patients with recurrent spontaneous abortion were enrolled in the study. 100 pregnant women with normal pregnancy history were enrolled in the study. The C677T polymorphism and HCY concentration of MTHFR gene were also detected. Results There was no specific genotype distribution of MTHFR in 100 cases of recurrent spontaneous abortion and 100 cases of normal pregnancy in this study. However, the HCY concentration was significantly different between the two groups. In TT genotype, HCY concentration was significantly increased. Conclusion HCY test can be used as an important monitoring indicator of recurrent spontaneous abortion.