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食管癌是全球常见的恶性肿瘤之一,在中国主要以鳞癌为主。虽然近年来食管鳞癌的早期诊断、手术治疗以及局部和全身的辅助治疗等方面的研究进展显著,但食管鳞癌的发病率和死亡率仍然居高不下,其中肿瘤的侵袭和转移是导致患者死亡的最主要原因。肿瘤细胞的侵袭和转移能力主要通过上皮间质转化(epithelial-mesenchymal transition,EMT)过程来获得。EMT是一个动态、多步骤和高度复杂的过程,其中涉及到肿瘤细胞基因、表观遗传学等的改变,这些改变与肿瘤的侵袭和转移密切相关。本文综述了食管鳞癌EMT与肿瘤侵袭转移的研究进展,旨在为食管鳞癌的诊断治疗研究积累基础理论资料。
Esophageal cancer is one of the common malignant tumors in the world, mainly squamous cell carcinoma in China. Although esophageal squamous cell carcinoma of the early diagnosis, surgical treatment and local and systemic adjuvant therapy and other aspects of the research progress is significant, but the incidence and mortality of esophageal squamous cell carcinoma is still high, in which invasion and metastasis of the tumor is leading to patients The main reason for death. The invasion and metastasis of tumor cells are mainly through epithelial-mesenchymal transition (EMT) process. EMT is a dynamic, multi-step and highly complex process involving changes in tumor cell genes, epigenetics, etc. These changes are closely related to tumor invasion and metastasis. This review summarizes the progress of EMT and invasion and metastasis of esophageal squamous cell carcinoma and aims to accumulate basic theoretical data for the diagnosis and treatment of esophageal squamous cell carcinoma.