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目的探讨蒽环类药物所致左心室功能障碍的早期诊断。方法应用多巴酚丁胺（ＤＯＢ）负荷多普勒超声心动图试验（ＤＳＴ）测定２３例患儿及１６例正常儿左室后壁增厚率（ＬＶＰＷＴ）、左室周边缩短率（ＶＣＦｃ）和左室收缩末期室壁应力（ＷＳ）。结果对照组ＬＶＰＷＴ、ＶＣＦｃ与ＤＯＢ输入速度呈正相关，ＷＳ与之呈负相关。患儿组仅ＶＣＦｃ与ＤＯＳ输入速度呈正相关，ＤＯＢ输入速度为５μｇ／（ｋｇ·ｍｉｎ）时，患儿组ＬＶＰＷＴ、ＶＣＦｃ显著低于对照组，ＷＳ无显著性差异。ＤＯＢ负荷情况下，４例患儿ＬＶＰＷＴ较基础值降低，其中１例伴ＶＣＦｃ降低和ＷＳ增高；３例伴ＷＳ增高；另有２例ＷＳ增高，１例ＶＣＦｃ降低。１０例患儿和１例正常儿出现轻微的不良反应。结论ＤＳＴ是安全、敏感的方法，能早期监测蒽环类药物引起的左室功能障碍
Objective To investigate the early diagnosis of anthracycline-induced left ventricular dysfunction. Methods The left ventricular wall thickening rate (LVPWT), left ventricle shortening rate (VCFc) and left ventricular wall thickening rate (LVPWT) were measured in 23 children and 16 normal children by Dob load Doppler echocardiography (DST) And left ventricular end systolic wall stress (WS). Results There was a positive correlation between LVPWT, VCFc and DOB input speed in control group, and WS negatively correlated with it. There was a positive correlation between VCFc and DOS input velocity in children group. LVPWT and VCFc in children group were significantly lower than those in control group when DOB input speed was 5μg / (kg · min). There was no significant difference in WS. In the case of DOB, the LVPWT in 4 cases was lower than the baseline. One case was accompanied by a decrease in VCFc and a rise in WS; three cases were accompanied by an increase in WS; another two cases were increased in WS and one case was decreased in VCFc. Ten patients and one normal child showed mild adverse reactions. Conclusions DST is a safe and sensitive method for early monitoring of anthracycline-induced left ventricular dysfunction