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本实验测定了28例正常妊娠,28例(中度或重度)妊高征病人的血小板聚集率及6-keto-PGF_1α和血栓烷B_2(TXB_2)的水平,以23例非妊娠者作对照。结果表明妊娠期血小板聚集率低。测定诱导后的血小板TXB_2生成比测定血浆TXB_2浓度更能反应血小板功能。设想PGE_2生成的增加可能与妊高征病人的精神症状有关。
In this study, the level of platelet aggregation and the levels of 6-keto-PGF_1α and TXB_2 in 28 normal pregnant women with 28 cases of (moderate or severe) PIH were measured. Twenty-three non-pregnant women served as controls. The results show that during pregnancy platelet aggregation rate is low. Determination of induced platelet TXB_2 generation than the determination of plasma concentrations of TXB_2 more responsive platelet function. It is hypothesized that the increased production of PGE 2 may be related to the psychiatric symptoms of patients with PIH.