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目的评价郑州市HIV/AIDS患者接受免费抗病毒治疗的效果。方法收集2004—2009年在我院接受抗病毒治疗的144例HIV/AIDS患者的临床资料并随访至2010年6月,比较分析治疗基线及治疗结束后CD4+T淋巴细胞水平、HIV载量变化,统计抗病毒治疗方案、机会性感染的发生、药物的不良反应等情况。结果 144例中,死亡12例;存活的132例中,102例HIV RNA<50copies/ml。132例存活患者CD4+T淋巴细胞计数在治疗前后比较差异有统计学意义。抗病毒治疗过程中发生药物不良反应109例次。目前达到病毒学治疗成功目标的102例中,91例采用一线抗病毒治疗方案。结论郑州市接受抗病毒治疗的绝大部分HIV/AIDS患者采用一线方案取得了良好的病毒学及免疫学效果,同时治疗过程中也出现了一定比例的不良反应。
Objective To evaluate the effect of free antiviral treatment in HIV / AIDS patients in Zhengzhou City. Methods The clinical data of 144 HIV / AIDS patients receiving antiretroviral therapy in our hospital from 2004 to 2009 were collected and followed up until June 2010. The levels of CD4 + T lymphocytes at baseline and after treatment were compared and the changes of HIV load , Statistical antiviral treatment programs, the occurrence of opportunistic infections, adverse drug reactions and so on. Results Of the 144 patients, 12 died and 102 survived 132 patients with HIV RNA <50 copies / ml. There were significant differences in CD4 + T lymphocyte count in 132 survivors before and after treatment. Antiviral therapy in the course of adverse drug reactions 109 cases. Of the 102 patients currently achieving the goal of virological treatment, 91 received first-line antiviral treatment. Conclusion The majority of HIV / AIDS patients receiving antiviral therapy in Zhengzhou have achieved good virological and immunological effects using the first-line regimen, and a certain proportion of adverse reactions have also appeared during the course of treatment.