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类肽是以N-取代甘氨酸为合成单元的类似多肽的非天然化合物。类肽保留了多肽可折叠可自组装的优点,同时类肽组成单元的多样性导致其结构多样性,使得类肽获得比多肽更多样的化学、生物活性。目前,其良好的生物活性和药理性质使得人们开始关注其在化学、生物和药学等领域应用。我们开发一种非朗缪尔槽的方法,利用少量样品就可以高效进行全自动和高通量的两维类肽纳米片层的制备,该方法可快速优化类肽自组装的条件,并可以用在其它肽类超分子的自组装研究。
Peptides are non-natural compounds like polypeptides that are synthesized from N-substituted glycines. Peptide retains the advantages of folding and self-assembly of peptides, while the diversity of peptide-like building blocks leads to its structural diversity, which allows the peptoid to acquire more diverse chemical and biological activities than the polypeptide. At present, its good biological activity and pharmacological properties make people start to pay attention to its application in the fields of chemistry, biology and pharmacy. We developed a non-Langmuir trough approach that efficiently and fully automated, high throughput, two-dimensional peptidomimetic nanosheet formation with a small sample size allows rapid optimization of the peptoid self-assembly conditions and allows Used in the self-assembly of other peptide supramolecules.