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目的:为了提高大黄素在体内的生物利用度,研制大黄素磁性纳米脂质体。方法:用薄膜-超声法制成大黄素磁性纳米脂质体。结果:大黄素磁性纳米脂质体粒径100-300nm,包封率33.75%。结论:用薄膜-超声法制成大黄素磁性纳米脂质体简便易行,大黄素的包封率仍有待进一步的提高。
Objective: In order to improve the bioavailability of emodin in vivo, emodin magnetic nanoparticles were developed. Methods: The emodin magnetic nano-liposomes were prepared by thin film-ultrasonic method. Results: The diameter of emodin magnetic nanoparticles was 100-300 nm and the encapsulation efficiency was 33.75%. CONCLUSION: The preparation of emodin magnetic nano-liposomes by membrane-ultrasonic method is simple and easy, and the encapsulation efficiency of emodin remains to be further improved.