滋养细胞肿瘤患者及其配偶的姐妹染色单体互换和核仁组织区活性研究

• 作 者: 舒静 张蕴璟 王秉正
• 机 构: 西安医科大学第一附属医院妇产科,西安医科大学第一附属医院妇产科,西安医科大学第一附属医院妇产科,
• 出 处: 肿瘤防治研究
• 发表日期: 1990年04期
• 关键词: 滋养细胞肿瘤 染色单体互换 良性葡萄胎 绒癌 绒毛膜癌 核仁组织区 活性影响 原癌基因 正常早孕妇女 完全性葡萄胎

本文对良性葡萄胎,恶性葡萄胎及绒毛膜癌患者和配偶同时进行了姐妹染色单体互换(SCE)及核仁组织区(NOR)活性研究。结果表明,恶葡和绒癌的发病可能与患者固有的DNA修复能力缺陷和DNA损伤有关;滋养细胞肿瘤的发生可能与患者具有的潜在的可被激活的NOR活性无关。虽然滋养细胞肿瘤的发病与受孕有密切的关系,但对配偶的SCE及NOR活性两方面的研究,未发现患者配偶的遗传物质整体水平特性与该肿瘤发病的关系。

In this study, sister chromatid exchange (SCE) and nucleolar activity (NOR) activity of benign hydatidiform mole, malignant mole and choriocarcinoma patients and their spouses were studied. The results showed that the incidence of malignant and choriocarcinoma may be related to DNA repair defects and DNA damage inherent in the patient; trophoblastic tumor may have nothing to do with the potential activation of NOR patients. Although the incidence of trophoblastic tumor is closely related to conception, the studies on the SCE and NOR activity of spouses did not find the relationship between the overall level of genetic material of spouse and the incidence of the tumor.