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缓释凝胶为溶剂敏感型原位凝胶,可将其注入到牙周袋内,通过基质的水合作用,使制剂固定黏附于牙周袋内,又通过基质的缓释性能,保证了其可在较长时间内释放活性成分,维持局部有效药物浓度。本文研究盐酸米诺环素缓释原位凝胶的材料筛选和工艺选择,并进行了处方优化。1仪器与试药1.1实验仪器:85-2A型恒温磁力加热搅拌器,SartoriusBS110S电子分析天平,光学显微镜。
The slow-release gel is a solvent-sensitive in situ gel that can be injected into the periodontal pocket to hydrate the matrix to immobilize the formulation in the periodontal pocket and through the sustained-release properties of the matrix It releases the active ingredient over a longer period of time, maintaining a locally effective drug concentration. In this paper, the material selection and process selection of minocycline hydrochloride in situ gel was studied and the prescription was optimized. 1 instruments and reagents 1.1 Experimental equipment: 85-2A type thermostat magnetic heating stirrer, SartoriusBS110S electronic analytical balance, optical microscope.