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目的:观察促性腺激素释放素激动剂(CnRH-a)与去氧孕烯炔雌醇治疗重度子宫内膜异位症(EM)的临床效果。方法:选择2012年4月至2014年8月收治的重度EM者90例,皆实施腹腔镜内保守手术,将患者平均分成对照组与研究组各45例,给予对照组单纯的CnRH-a疗法,研究组在对照组基础上加用妈富隆治疗,随访患者1年后对比其术前与术后1年的内分泌激素水平包括黄体生成素(LH)、卵泡雌激素(FSH)、雌二醇(E2)及围绝经期的症状严重程度及主观感受。结果:两组患者手术前LH、FSH、E2水平比较,差异无统计学意义(P>0.05),术后皆有所下降(P<0.05);术后两组围绝经期的症状严重程度及主观感受比较,差异无统计学意义(P>0.05)。结论:妈富隆可有效缓解重度EM患者低雌激素症状及疼痛症状。
Objective: To observe the clinical effect of gonadotropin-releasing hormone agonist (CnRH-a) and desogestrel ethinyl estradiol in the treatment of severe endometriosis (EM). Methods: Ninety patients with severe EM who were admitted from April 2012 to August 2014 were enrolled in this study. All patients underwent laparoscopic conservative surgery. The patients were equally divided into control group and study group, 45 cases each. Patients in control group were treated with CnRH-a . The study group was treated with Marvelon on the basis of the control group. The level of endocrine hormones including luteinizing hormone (LH), follicular estrogen (FSH), estradiol (E2) and perimenopausal symptoms of the severity and subjective feelings. Results: There was no significant difference in the levels of LH, FSH and E2 between the two groups before surgery (P> 0.05), but both postoperatively (P <0.05). The severity of postmenopausal symptoms, Subjective feelings of comparison, the difference was not statistically significant (P> 0.05). Conclusion: Marvelon can effectively alleviate the symptoms of low estrogen and pain in patients with severe EM.