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目的 测定大骨节病（Ｋａｓｈｉｎ－Ｂｅｃｋ Ｄｉｓｅａｓｅ，ＫＢＤ）区与非病区儿童发中３９ 种元素的含量，用Ｌｏｇｉｓｔｉｃ 统计分析，以探讨硒等化学元素与ＫＢＤ 的关系。方法 采用病例对照研究，用ＩＣＰ－ＭＳ法检测ＫＢＤ 病区与非病区６～１４ 岁５ 个组１５０ 名男童发中３９ 种元素含量。结果 ＫＢＤ区儿童发硒、硼、碘显著低于非病区，而镁、铁、锰、钴、钒、锂含量依ＫＢＤ 患儿、病区健康儿童、非病区健康儿童递减。病区铝、镍、钍显著高于非病区；Ｌｏｇｉｓｔｉｃ 回归筛选出钙、钠、锗、铜、铁、硼、锂、铬、硒、锑、铅、锡１２ 种与ＫＢＤ 患病可能有关的元素。结论 除发硒含量低之外，ＫＢＤ有多种营养元素和毒性元素的失衡。
Objective To determine the content of 39 elements in children with Kashin-Beck Disease (KBD) and non-ward children and to explore the relationship between the chemical elements such as selenium and KBD using Logistic statistical analysis. Methods A case-control study was conducted. The contents of 39 elements in 150 boys from 5 to 6-year-olds in KBD and non-ward were detected by ICP-MS. Results The children with KBD developed selenium, boron and iodine significantly lower than those of non-endemic area. The contents of magnesium, iron, manganese, cobalt, vanadium and lithium in KBD children were decreased in children with KBD, in healthy children and in non-endemic children. Logistic regression showed that 12 species of calcium, sodium, germanium, copper, iron, boron, lithium, chromium, selenium, antimony, lead and tin could be related to the prevalence of KBD element. Conclusion In addition to selenium content is low, KBD has a variety of nutrients and toxic elements of the imbalance.