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目的系统评价加替沙星对比左氧氟沙星治疗细菌性结膜炎疗效与安全性。设计系统综述。研究对象检索中国生物医学文献数据库、中国期刊全文数据库(CNKI)、万方医药期刊全文数据库、中文科技期刊数据库、Pub Med、Cochrane Library、Embase。收集加替沙星对比左氧氟沙星治疗细菌性结膜炎的临床随机对照研究(RCT)。方法根据纳入和排除标准筛选文献,对符合条件的RCT由两位研究者独立进行资料提取和质量评价后,采用Cochrane协作网提供的Rev Man 5.3与Stata12.0进行Meta分析。主要指标治愈率、痊愈率、不良反应。结果加替沙星组治愈率(OR=3.20,95%CI为2.37~4.31,P<0.00001)与痊愈率(OR=1.88,95%CI为1.56~2.27,P<0.00001)较左氧氟沙星组均较高,并能降低总不良反应的发生(OR=0.47,95%CI为0.27~0.80,P=0.006)。而眼睛刺痛(OR=0.76,95%CI为0.37~1.57,P=0.46)、眼痒(OR=0.32,95%CI为0.10~1.00,P=0.05)等不良反应指标在两组中无差异。结论加替沙星在治疗细菌性结膜炎方面,与左氧氟沙星相比疗效好,不良反应少。
Objective To evaluate the efficacy and safety of gatifloxacin versus levofloxacin in the treatment of bacterial conjunctivitis. Design System Review. Subjects were searched China Biomedical Literature Database, Chinese Journal Full-text Database (CNKI), Wanfang Pharmaceutical Journal Full-text Database, Chinese Science and Technology Periodical Database, Pub Med, Cochrane Library, Embase. A clinical randomized controlled study (RCT) of gatifloxacin versus levofloxacin in the treatment of bacterial conjunctivitis. Methods Based on the inclusion and exclusion criteria, the eligible RCTs were independently extracted by two investigators and evaluated for quality. Meta-analysis was performed using Rev Man 5.3 and Stata12.0 provided by the Cochrane Collaboration. The main indicators of cure rate, cure rate, adverse reactions. Results Compared with levofloxacin group, the cure rate (OR = 3.20, 95% CI 2.37-4.31, P <0.00001) and cure rate (OR = 1.88, 95% CI 1.56-2.227, P <0.00001) (OR = 0.47, 95% CI 0.27-0.80, P = 0.006). There was no significant difference in adverse reactions such as eye sting (OR = 0.76, 95% CI 0.37-1.57, P = 0.46), itchy itchy eye (OR = 0.32, 95% CI 0.10-1.00, P = difference. Conclusion Gatifloxacin has better curative effect and less side effects than levofloxacin in the treatment of bacterial conjunctivitis.