二甲双胍治疗多囊卵巢综合征胰岛素抵抗的临床观察

• 作 者: 陶建英 徐惠民
• 机 构: 苏州市妇幼保健院妇产科,苏州大学附属第二医院妇产科 苏州215004,苏州215004
• 出 处: 苏州大学学报(医学版)
• 发表日期: 2003年02期
• 关键词: 多囊卵巢综合征 胰岛素抵抗 二甲双胍

目的　观察二甲双胍治疗多囊卵巢综合征胰岛素抵抗患者的临床疗效。方法　对 2 0例多囊卵巢综合征胰岛素抵抗患者 ,进行 12周的二甲双胍治疗 ,比较治疗前后的体重指数、基础胰岛素、生殖激素水平与排卵率的变化。结果　治疗 12周后 ,基础胰岛素水平从 19.71± 6 .2 7mU/L降至 14 .95± 5 .4 3mU/L(P <0 .0 2 ) ,LH从 18.2 0± 6 .91mU/L降至 13.17± 3.75mU/L(P <0 .0 1) ,睾酮从 1.89± 0 .4 3nmol/L降至 1.5 3± 0 .39nmol/L(P <0 .0 2 )。 2 0例月经稀发的患者 ,16例恢复排卵 ,排卵率 5 3%。结论　二甲双胍可改善胰岛素敏感性 ,降低血胰岛素水平 ,进而纠正了高雄激素血症等内分泌紊乱 ,恢复有排卵月经

Objective To observe the clinical efficacy of metformin in the treatment of insulin resistance patients with polycystic ovary syndrome. Methods Twenty patients with polycystic ovary syndrome and insulin resistance were treated with metformin for 12 weeks. The changes of body mass index, basal insulin, reproductive hormone and ovulation rate before and after treatment were compared. Results After 12 weeks of treatment, basal insulin levels decreased from 19.71 ± 6.27mU / L to 14.95 ± 5.34mU / L (P <0. 02) and LH decreased from 18.2 ± 6.91mU / L To 13.17 ± 3.75mU / L (P <0.01), testosterone decreased from 1.89 ± 0.4nmol / L to 1.53 ± 0.39nmol / L (P <0. Twenty cases of oligomenorrhea patients, 16 cases of ovulation recovery, ovulation rate of 53%. Conclusion Metformin can improve insulin sensitivity, reduce blood insulin levels, and thus correct the hyperandrogenism and other endocrine disorders, restore ovulation menstruation