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目的观察乙肝病毒相关性肾炎(HBV-MN)与特发性膜性肾病(IMN)的病理特点,并进行2组比较。方法选取医院经临床及肾活检病理明确诊断的60例患者,其中30例为乙肝病毒相关性肾炎患者,30例为特发性膜性肾病患者,对2组临床资料进行分析,比较2组的临床病理特点。结果乙肝病毒相关性肾炎患者与特发性膜性肾病患者的发病年龄具有显著差异,乙肝病毒性相关性肾炎患者发病年龄更小,平均年龄(37.3±13.6)岁,乙肝病毒相关性肾炎伴发系膜增生较为常见,与特发性膜性肾病有差异,免疫复合物沉积在特发性膜性肾病中较为常见,2组在肾组织沉积率上(IgG、IgM、IgA、C3、C1q、FRA)比较,差异均有统计学意义(P<0.05)。结论在临床上乙肝病毒相关性肾炎与特发性膜性肾病的临床表现相似,诊断时易发生误诊,需结合两者不同的病理特点来辅助诊断。
Objective To observe the pathological characteristics of hepatitis B virus associated nephritis (HBV-MN) and idiopathic membranous nephropathy (IMN), and to compare the two groups. Methods Sixty patients with clinically diagnosed renal biopsy were enrolled in this study. Among them, 30 were hepatitis B virus-associated nephritis and 30 were idiopathic membranous nephropathy. The clinical data of 2 groups were compared. Clinical and pathological features. Results The age of onset of patients with idiopathic membranous nephropathy was significantly different from that of patients with idiopathic membranous nephropathy. The incidence of hepatitis B virus-associated nephritis was younger, with an average age of 37.3 ± 13.6 years and hepatitis B virus-associated nephritis Mesangial hyperplasia is more common, and idiopathic membranous nephropathy are different, the immune complex deposition in idiopathic membranous nephropathy is more common in the deposition rate of the two groups (IgG, IgM, IgA, C3, C1q, FRA), the differences were statistically significant (P <0.05). Conclusions In clinic, the clinical manifestations of HBV-associated nephritis and idiopathic membranous nephropathy are similar. Misdiagnosis is easy to diagnose. Combined with the different pathological features of both, the diagnosis should be supported.