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临床常用噻嗪类特别是冬眠灵治疗精神失常,此类药物可引起许多不良反应。近代发现此药可产生巨结肠或巨乙状结肠综合征,此综合征表现为小肠、结肠、盲肠梗阻,此种假性肠梗阻,使钡剂延长8～10天存留时间。如须做手术,术后可延长梗阻时间10～14天,且只能用洗肠及胃肠减压才能缓解。此种假性肠梗阻或麻痹性肠梗阻尤多见于长期用噻嗪类药物的病人。噻嗪类药物可阻滞胃肠道功能,使小肠、结肠蠕动停止,使盲肠明显扩张。用抗胆碱酯酶类药物,斯的明可使阻滞解除80％以上。
Clinical commonly used thiazides, especially the winter spirit treatment of mental disorders, such drugs can cause a lot of adverse reactions. Modern discovery of this medicine can produce megacolon or sigmoid syndrome, the syndrome manifested as small intestine, colon, cecal obstruction, this pseudo-intestinal obstruction, barium extended to 8 to 10 days retention time. Such as surgery, postoperative extension of obstruction can be 10 to 14 days, and only with hydrotherapy and gastrointestinal decompression can be alleviated. Such pseudo-intestinal obstruction or paralytic ileus is more common in patients with long-term thiazide drugs. Thiazide drugs can block the gastrointestinal function, so that the small intestine, colon peristalsis stopped, so that significant expansion of the cecum. With anticholinesterase drugs, Sri Lanka can block the lifting of more than 80%.