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目的:观察自拟中药方联合布地奈德吸入治疗小儿毛细支气管炎的临床疗效,观察患者症状或体征改善时间状况。方法:选择本院2011年1月~2014年4月小儿毛细支气管炎患者128例,根据治疗方法分为对照组(60例)和治疗组(68例),对照组应用布地奈德吸入治疗。治疗组应用自拟中药方联合布地奈德吸入治疗。主要评估临床治疗效果、主要症状或体征评分及消失时间、住院时间等。结果:治疗组治愈率为82.35%,高于对照组65.00%(P<0.05);治疗组住院时间为(7.44±0.83)天,低于对照组(9.18±0.92)天(P<0.05);治疗组治疗后哮喘症状和气道反应性评分分别为0.73±0.15和0.71±0.20,均低于对照组治疗后1.29±0.18和1.22±0.26(P<0.05)。治疗组患者咳嗽、气促缓解、喘憋及肺部体征消失时间分别为5.01±0.77天、3.14±0.38天、3.65±0.46天和5.42±0.97天,均低于对照组(P<0.05)。结论:自拟中药方联合布地奈德吸入治疗小儿毛细支气管炎的临床疗效观察效果显著,通过化痰止咳、清热宣肺、祛邪固表,可明显改善患者症状或体征,缩短患者治疗时间。
OBJECTIVE: To observe the clinical efficacy of self-made traditional Chinese medicine combined with budesonide inhalation in the treatment of pediatric bronchiolitis and to observe the improvement of the symptoms or signs of patients. Methods: A total of 128 pediatric patients with bronchiolitis from January 2011 to April 2014 were selected and divided into control group (60 cases) and treatment group (68 cases). The control group was treated with budesonide inhalation. The treatment group applied self-made Chinese medicine combined with budesonide inhalation therapy. The main assessment of clinical treatment, the main symptoms or signs score and disappear time, hospitalization time. Results: The cure rate in the treatment group was 82.35%, which was higher than 65.00% in the control group (P <0.05). The hospitalization time in the treatment group was (7.44 ± 0.83) days, which was lower than that in the control group (9.18 ± 0.92) days (P <0.05). The asthma symptoms and airway responsiveness score of the treatment group were 0.73 ± 0.15 and 0.71 ± 0.20, respectively, which were lower than those of the control group after treatment (1.29 ± 0.18 and 1.22 ± 0.26, P <0.05). Patients in the treatment group had cough, relief of shortness of breath, wheezing and disappearance of lung signs were 5.01 ± 0.77 days, 3.14 ± 0.38 days, 3.65 ± 0.46 days and 5.42 ± 0.97 days, respectively, which were all lower than those in the control group (P <0.05). CONCLUSION: The curative effect of self-made Chinese medicine combined with budesonide inhalation on children with bronchiolitis is remarkable. The symptoms and signs of patients with bronchiolitis can be markedly alleviated through the treatment of phlegm and relieving cough, clearing away heat and dispelling the lungs, removing the evil and fixing the symptoms, and shortening the treatment time.