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目的探讨湖北省当阳市乙肝母婴传播阻断工作状况,制定乙肝母婴传播阻断措施。方法阻断组在孕7、8、9个月分别肌注乙肝免疫球蛋白200IU/次,婴儿出生后在按常规接种乙肝疫苗3次(0、1、6个月),同时婴儿在出生24小时内1次肌注乙肝免疫球蛋白100IU;非阻断组在孕前、产时不做特殊处理,只在婴儿出生后按常规接种乙肝疫苗3次(0、1、6个月),观察婴儿乙肝病毒感染情况。结果阻断组婴儿315例有11例感染乙型肝炎病毒,感染率为3.49%;非阻断组婴儿106例有22例感染乙肝病毒,感染率为20.75%。两者经统计学检验,2χ=26.02,P<0.01,有极显著性差异。结论乙肝表面抗原阳性孕妇采取乙肝母婴传播阻断措施能减少母婴垂直传播机会。
Objective To investigate the status of mother-to-child transmission of hepatitis B virus in Dangyang City, Hubei Province, and to establish a measure of blocking the transmission of hepatitis B virus. Methods The blocking group received intramuscular injection of hepatitis B immunoglobulin (200 IU) at 7, 8, and 9 months of gestation, and the babies were vaccinated three times (0, 1 and 6 months) 1 intramuscular hepatitis B immunoglobulin 100IU intramuscularly within 1 hour; non-blocking group before pregnancy, during production without special treatment, only after the birth of the baby was routinely vaccinated hepatitis B vaccine 3 times (0,1,6 months), observe the infant Hepatitis B virus infection. Results In the blockage group, 315 infants had 11 cases of hepatitis B virus infection, the infection rate was 3.49%. In non-blocking infants, 22 cases were infected with hepatitis B virus and the infection rate was 20.75%. The two statistically test, 2χ = 26.02, P <0.01, a very significant difference. Conclusion Hepatitis B surface antigen-positive pregnant women taking mother-to-child transmission of hepatitis B can reduce the chance of vertical transmission of mother and baby.