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测定33例哮喘患儿和10例健康儿血液细胞间粘附因子(ICAM-1)、IL-4和IgE。结果:哮喘发作组ICAM-1、IL-4和IgE分别为527.79±443.22ng/ml、245.99±116.86pg/ml和1270.90±1299.87U/ml;哮喘缓解组分别为433.51±377.38ng/ml、192.98±112.25pg/ml和362.62±231.99U/ml;健康对照组分别为214.17±78.61ng/ml、131.472±36.35pg/ml和133.09±118.99U/ml。发作组与对照组三指标相比有显著性差异;发作组与缓解组及缓解组与对照组之间仅IgE有显著性差异。各组三指标之间除发作组IgE与IL-4呈显著正相关外,余均无显著性相关。提示ICAM-1、IL-4和总IgE升高是哮喘过敏性炎症的表现;研究ICAM-1、IL-4的拮抗剂对哮喘治疗有积极意义。
The ICAM-1, IL-4 and IgE in 33 asthmatic children and 10 healthy children were determined. Results: The levels of ICAM-1, IL-4 and IgE in the asthma attack group were 527.79 ± 443.22ng / ml, 245.99 ± 116.86pg / ml and 1270.90 ± 1299.87U / ml respectively. The asthma relief group was 433.51 ± 377.38ng / ml and 192.98 ± 112.25 pg / ml and 362.62 ± 231.99 U / ml; healthy controls were 214.17 ± 78.61 ng / ml, 131.472 ± 36.35 pg / ml and 133.09 ± 118.99 U / ml, respectively. There were significant differences between the three groups in the attack group and the control group; there was only significant difference in the IgE between the attack group and the remission group and the remission group and the control group. There was no significant correlation between IgE and IL-4 in all groups except for the seizure group. It is suggested that the increase of ICAM-1, IL-4 and total IgE are the manifestations of allergic inflammation in asthma. It is of great significance to study the effect of ICAM-1 and IL-4 antagonists on the treatment of asthma.