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目的:探讨小剂量奥美拉唑治疗功能性消化不良(FD)的疗效及安全性。方法:96例FD患者随机分为2组,口服小剂量奥美拉唑48例(观察组),10 mg,1次/日;口服多潘立酮48例(对照组),10 mg/次,3次/日。疗程均为2周。观察两组患者症状改善程度及不良反应。结果:观察组与对照组患者治疗后胃部烧灼感、餐后饱胀、上腹痛、嗳气症状评分均较前明显改善,差异有统计学意义。临床总有效率分别为68.9%、70.8%,差异无统计学意义。对照组不良反应发生率高于观察组,差异具有统计学意义。结论:小剂量奥美拉唑治疗FD疗效较好,不良反应少,值得临床推广应用。
Objective: To investigate the efficacy and safety of low-dose omeprazole in the treatment of functional dyspepsia (FD). Methods: A total of 96 patients with FD were randomly divided into two groups: oral small-dose omeprazole 48 cases (observation group), 10 mg once daily; oral domperidone 48 cases (control group), 10 mg / /day. The course of treatment is 2 weeks. Two groups of patients to observe the degree of improvement and adverse reactions. Results: The scores of stomach burning sensation, postprandial fullness, upper abdominal pain and belching symptom of observation group and control group were significantly improved after treatment, the difference was statistically significant. The total clinical effective rate was 68.9%, 70.8%, the difference was not statistically significant. The incidence of adverse reactions in the control group was higher than that in the observation group, the difference was statistically significant. Conclusion: The low-dose omeprazole treatment of FD better efficacy, fewer adverse reactions, worthy of clinical application.