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位置偏爱实验(Conditioned Place Preference)是80年代出现的一种评价药物精神依赖性潜力的方法。本文用此法评价了国产新药氢埃托啡(DHE)的精神依赖性潜力。实验在隔音、通风的箱中进行,周期为6 d。前5 d训练,第6 d观察动物对位置的选择,训练在黑白盒中进行,其它程序如下:每只动物每日上、下午分别注射一针,其中一针为受试药物,另一为盐水(对照组均使用盐水),受试动物的注射时间是固定的。给药后,将动物放在黑色盒中(伴药盒),给盐水后放在白色盒中,训练时间为50min。第6 d,在动物给药的时
The Conditioned Place Preference, a method developed in the 1980s to evaluate the potential of drug dependence in the mind. This article evaluates the psychic dependence potential of the domestic new drug dehydroetorphine (DHE). The experiment was conducted in a soundproof and ventilated box with a period of 6 days. The first 5 days of training, the first 6 days observation of animals on the location of choice, training in black and white box, the other programs are as follows: Each animal daily, afternoon injection of a needle, one needle for the test drug, and the other Saline (control group using saline), injection time of the test animals is fixed. After administration, the animals were placed in a black box (with kit), saline, and placed in a white box for a training time of 50 min. Day 6 d, at the time of animal administration