论文部分内容阅读
国内外对细菌脂多糖的研究由来已久,但大多数脂多糖均因毒性较大而难于在临床上应用。1906年Coley最早报导了粘质赛氏杆菌(Serratia marcescens)及溶链菌提取物对人肉瘤有治疗作用。此后各国学者陆续对它进行了研究。 近年来苏联及日本学者相继报导了由神灵杆菌(Bacterium prodigiosum)提取的脂多糖的实验研究结果。1974年我们从国内现有的神灵杆菌经过筛选用产色型培养获得了脂多糖,定名为灵菌素。由实验和临
Domestic and foreign research on bacterial lipopolysaccharide has been a long time, but most of the lipopolysaccharide are toxic due to its greater difficulty in clinical application. Coley was the first to report on the treatment of human sarcoma with Serratia marcescens and lysozyme extracts in 1906. Since then, scholars from all over the world have studied it. In recent years, Soviet and Japanese scholars have reported the experimental results of lipopolysaccharide extracted from Bacterium prodigiosum one after another. In 1974, we obtained the lipopolysaccharide from the existing deodorant bacterium in our country through the selection of production-type culture, and named it as Lingcomycin. By experiment and Pro