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目的:比较胸腔镜肺癌根治术和传统开胸肺癌根治术治疗肺癌的临床疗效并探讨其可能作用机制。方法:选取2011年3月至2015年3月于本院进行肺癌根治术的120例患者为研究对象,随机分为观察组(胸腔镜手术组)60例与对照组(开胸手术组)60例,比较两组的手术时间、术中出血量、术后引流量和引流管留置时间;并比较两组患者术前1 d及术后1 d、3 d、7 d的血清炎症因子和疼痛物质水平的变化。结果:两组患者在手术时间、手术出血量和术后引流等临床指标方面差异无明显统计学意义(P>0.05);两组肺癌患者术前1 d的血清炎症因子和疼痛物质水平比较无明显统计学意义(P>0.05),而术后1 d、3 d及7 d胸腔镜手术组的细胞炎症因子及疼痛物质血清表达水平均低于对照组(P<0.05),血液流变指标较小,存在显著差异(P<0.05)。结论:相较于传统开胸根治术,胸腔镜肺癌根治术不仅减少了患者体表创口,亦减小了患者的炎症反应和应激反应,且对血液循环的影响亦较小。
Objective: To compare the clinical efficacy of thoracoscopic lung cancer radical mastectomy and conventional open-chest lung cancer radical mastectomy for lung cancer and to explore its possible mechanism. Methods: A total of 120 patients undergoing radical resection of lung cancer from March 2011 to March 2015 in our hospital were selected and randomly divided into observation group (thoracoscopic surgery group) 60 cases and control group (thoracotomy group) 60 For example, the operation time, intraoperative blood loss, postoperative drainage volume and drainage tube indwelling time were compared between the two groups. Serum inflammatory factors and pain were compared on the first day before operation and on the 1st, 3rd, and 7th after operation Changes in material levels. Results: There was no significant difference between the two groups in clinical parameters such as operation time, blood loss after operation and postoperative drainage (P> 0.05). The levels of inflammatory cytokines and pain substances in the two groups of patients before operation were statistically different (P> 0.05). The levels of inflammatory cytokines and pain substances in the thoracoscopic surgery group at 1 d, 3 d and 7 d after operation were significantly lower than those in the control group (P <0.05). The indexes of hemorheology Smaller, there was a significant difference (P <0.05). Conclusion: Compared with the conventional thoracotomy, thoracoscopic radical resection of lung cancer not only reduces the body surface wounds, but also reduces the patient’s inflammatory response and stress response, and the impact on blood circulation is also small.