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本文对地高辛维持量疗法治疗1056例心力衰竭中发生中毒反应的97例进行了分析。中毒发生率和中毒死亡率分别为9.2％和6.2％,中毒病例中,心律失常发生率95.9％。6例均死于严重心律失常。62例心衰病例的血清地高辛放射免疫测定结果表明,它是判断洋地黄中毒的一个重要而可靠的方法。对4例中毒早期表现为尿少症者的测定,发现血清地高辛浓度与尿量减少程度呈负相关,r=-1(P<0.01),回归方程为Y=5.1-0.06X。分析了地高辛维持量疗法反应轻、死亡率低的原因,讨论了中毒的表现、诱因及其机理。
In this paper, 97 cases of toxic reactions in 1056 cases of heart failure treated with digoxin maintenance therapy were analyzed. The incidence of poisoning and poisoning were 9.2% and 6.2%, respectively. In the poisoning cases, the incidence of arrhythmia was 95.9%. Six patients died of severe arrhythmia. 62 cases of heart failure serum digoxin radioimmunoassay results show that it is to determine digitalis poisoning is an important and reliable method. 4 cases of early poisoning manifested as oliguria in the determination of serum digoxin concentration was found to be negatively correlated with the decrease in urine output, r = -1 (P <0.01), the regression equation was Y = 5.1-0.06X. The reasons of low reaction rate and low mortality rate of digoxin maintenance therapy were analyzed. The manifestation, inducement and mechanism of poisoning were discussed.