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目的:评价小剂量平阳霉素多次注射治疗婴幼儿腮腺血管瘤的临床疗效。方法:回顾分析2001—2011年间行小剂量低浓度平阳霉素+地塞米松瘤内注射治疗的78例增殖早期腮腺血管瘤患儿。分别用数码照片和MRI记录治疗前、后病变的面积,随访时间为0.5-10 a。按初诊年龄分为4组,比较用药剂量、治疗次数和时间,以及家长满意度。应用SPSS 13.0软件包对数据进行统计学分析。结果:治疗后大部分血管瘤体积明显减小,MRI检查显示瘤体组织纤维化。治愈67例(85.9%),显效11例(14.1%),总有效率为100%。仅15例出现食欲缺乏、发热和皮疹等不良反应。低年龄组治疗持续时间为(4.73±0.11)个月,注射总剂量为(2.82±0.12)mL,显著低于其他3组(P<0.05),家长满意度高。结论:小剂量平阳霉素多次注射治疗法对婴幼儿腮腺巨大血管瘤的疗效安全可靠。患儿接受治疗的时间越早,用药剂量越小,疗程越短,家长满意度越高。
Objective: To evaluate the clinical efficacy of multiple injections of Pingyangmycin in small dose treatment of parotid hemangiomas in infants and young children. Methods: A retrospective analysis of 78 cases of proliferative early parotid hemangiomas treated with intratracheal injections of low-dose pingyangmycin plus dexamethasone in 2001-2011. Respectively, digital photographs and MRI were recorded before and after treatment of lesion area, follow-up time was 0.5-10 a. According to the age of newly diagnosed patients were divided into 4 groups, compare the dosage, treatment times and time, and parents satisfaction. Data were statistically analyzed using SPSS 13.0 software package. Results: After treatment, the volume of most hemangiomas was significantly reduced, and MRI showed fibrosis of the tumor tissues. 67 cases were cured (85.9%), markedly effective in 11 cases (14.1%), the total effective rate was 100%. Only 15 cases of appetite deficiency, fever and rash and other adverse reactions. The duration of treatment in low-age group was (4.73 ± 0.11) months, the total dose of injection was (2.82 ± 0.12) mL, significantly lower than the other three groups (P <0.05). Conclusions: The low-dose pingyangmycin multiple injections treatment is safe and reliable for infantile parotid giant hemangiomas. Children receive treatment earlier, the smaller the dose, the shorter the course of treatment, the higher the satisfaction of parents.