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检测732名产妇血中HCV标记,抗HCV(ELISA)和HCVRNA(PCR)均阳性者33例(33/732,4.5%),其所生的33名新生儿中有23名的脐血检到HCVRNA(23/33,69.7%)。对其中27例新生儿的随访(平均19.6月)表明,母婴传播感染的22例新生儿,HCV病毒血症在出生后逐渐阴转,血清HCVRNA阳性率(KaplanMeier法计算)6月龄时为81.8%,12月龄时为45.0%,18月龄时为30.0%,30月龄为16%,提示这些新生儿的HCV感染发生于产前或分娩时的可能性。新生儿体内来自母体的IgG类抗HCV抗体出生后3个月即已基本阴转;婴儿本身在随访期间未检到有此类抗HCV的产生。随访婴儿血清ALT水平均正常,提示HCV母婴传播感染的婴儿呈亚临床状态。
333 (33/732, 4.5%) were positive for anti-HCV (ELISA) and HCVRNA (HCV) in 732 maternal blood samples, and 23 of the 33 newborn infants Blood samples were collected for HCV RNA (23/33, 69.7%). The follow-up of 27 newborns (mean, 19.6 months) showed that 22 newborns with mother-to-child transmission of HCV viremia gradually became negative after birth, and the positive rate of serum HCV RNA (calculated by Kaplan-Meier) 81.8% at month, 45.0% at 12 months of age, 30.0% at 18 months of age and 16% at 30 months of age, suggesting that HCV infection in these newborns occurred during prenatal or childbirth The possibility of. Neonatal body from the mother’s IgG anti-HCV antibodies 3 months after birth has basically inverted; the baby itself was not detected during follow-up of such anti-HCV. Follow-up baby serum ALT levels were normal, suggesting that infants infected with HCV maternal and child transmission was subclinical.