【摘 要】
：
缺血性心脏病(IHD)是一种在世界范围内高发的疾病,近年来其治疗研究的进展突飞猛进,其中应用干细胞治疗该病的报道越来越多,而如何提高该治疗手段的疗效成为许多医疗工作者关
【机 构】
：
南京大学医学院附属鼓楼医院心胸外科,
论文部分内容阅读
缺血性心脏病(IHD)是一种在世界范围内高发的疾病,近年来其治疗研究的进展突飞猛进,其中应用干细胞治疗该病的报道越来越多,而如何提高该治疗手段的疗效成为许多医疗工作者关注的焦点。基质细胞衍生因子1(SDF-1)是目前已知的唯一与干细胞动员有关的趋化因子,它可以通过与其特异性受体CXCR4结合激活一系列信号通路,从而在组织缺血后起到炎症调节、促进干细胞动员、诱导血管再生的作用,引起了研究者们极大的兴趣。本文介绍了SDF-1/CXCR4轴在不同类型缺血性心脏病中的病理生理变化及临床应用。
Ischemic heart disease (IHD) is a worldwide endemic disease that has seen tremendous progress in its therapeutic research in recent years. Among them, there are more and more reports about the application of stem cells in the treatment of this disease and how to improve the therapeutic effect of this treatment Many medical workers are focused. Stromal cell-derived factor 1 (SDF-1) is the only chemokine known to be involved in stem cell mobilization. It activates a series of signaling pathways through binding to its specific receptor CXCR4, thereby contributing to inflammation after tissue ischemia Regulate, promote stem cell mobilization, induce angiogenesis, aroused great interest of researchers. This article describes the SDF-1 / CXCR4 axis in different types of ischemic heart disease pathophysiological changes and clinical applications.
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