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目的探讨维吾尔族与汉族经直肠超声引导的前列腺穿刺中前列腺特异性抗原(PSA)、年龄、前列腺体积(PV)、前列腺特异性抗原密度(PSAD)与前列腺癌(Pca)检出率的关系。方法分析2007年5月-2014年10月在新疆医科大学第一附属医院行前列腺穿刺635例患者的临床资料,其中维吾尔族142例,汉族493例。所有穿刺病例在行穿刺术前均行前列腺特异性抗原(PSA)、直肠指诊(DRE)及经直肠超声(TRus)扫描测量PV水平并计算得出前列腺特异性抗原密度(PSAD),分析维、汉族PSA、年龄、PSAD、Pv与Pca检出率的关系。结果汉族病理结果前列腺增生290例,前列腺癌203例,总检出率为41.1%;维吾尔族病理结果前列腺增生92例,前列腺癌50例,总检出率为35.2%。汉族和维吾尔族前列腺癌穿刺阳性率差异无统计学意义(P>0.05)。维、汉族前列腺癌穿刺阳性率与年龄、TPSA、FPSA和PSAD呈显著正相关,与前列腺体积呈负相关。经多因素非条件Logistic回归分析;年龄、TPSA、前列腺体积可影响前列腺癌检出率(OR值分别为1.134、1.056、0.969,95%CI分别为0.039~0.211、0.004~0.106、-0.048~-0.016,P均<0.05)。结论维、汉族前列腺癌的穿刺阳性率随着年龄、TPSA、PSAD的增高而增加,而前列腺体积越大,阳性率则越低;两民族间前列腺癌检出率无差异。年龄、TPSA、前列腺体积可能是Pca发生的独立危险因素。
Objective To investigate the relationship between prostate specific antigen (PSA), age, prostate volume (PV), prostate specific antigen density (PSAD) and the detection rate of prostate cancer (Pca) in transrectal ultrasound-guided Uygur and Han patients. Methods Clinical data of 635 cases of prostate biopsy in the First Affiliated Hospital of Xinjiang Medical University from May 2007 to October 2014 were analyzed, including 142 Uygur nationality patients and 493 Han nationality patients. All patients underwent puncture before prostatectomy. Prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound (TRus) scan were performed to measure the level of PV and calculate prostate specific antigen density (PSAD) , Han PSA, age, PSAD, Pv and Pca detection rate. Results There were 290 cases of benign prostatic hyperplasia and 203 cases of prostate cancer in Han nationality. The total detection rate was 41.1%. The pathological findings of Uygur patients included 92 cases of benign prostatic hyperplasia and 50 cases of prostate cancer. The total detection rate was 35.2%. There was no significant difference in the positive rate of prostate cancer between Han and Uygur (P> 0.05). There was a significant positive correlation between the positive rate of prostate cancer and the age, TPSA, FPSA and PSAD in Victoria and Han nationality, but negatively correlated with prostate volume. Multivariate non-conditional Logistic regression analysis showed that age, TPSA and prostate volume could influence the detection rate of prostate cancer (OR = 1.134,1.056,0.969, 95% CI 0.039-0.211,0.004-0.106,0.048 ~ 0.016, P <0.05). Conclusions The positive rate of prostatic cancer in Uygur and Han nationality patients increases with the increase of age, TPSA and PSAD. The larger the prostate volume is, the lower the positive rate is. There is no difference between the two ethnic groups in the detection rate of prostate cancer. Age, TPSA, and prostate volume may be independent risk factors for Pca.