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目的 研究 6 0℃灌注液经肝动脉行灌注性热疗后 ,肝功各项指标的变化情况 ,为临床灌注性热化疗提供安全数据 .方法 经犬肝动脉 (n=10 )灌注入 6 0℃生理盐水 2 0 0m L ,30 min灌完 .分别于灌注前及灌注后 1,3,5 ,7d检查肝功的动态变化情况 .结果 DSA示肝动脉扩张 ,肝实质显影延迟 ;AL T,AST于灌注后开始升高 (AL T 10倍、AST 3倍 ) ,之后逐渐恢复 ,1wk后全部恢复正常 ,而胆红素、白蛋白及 γ-GT则无明显变化 .结论 经肝动脉 6 0℃介入性热疗对肝脏损伤轻微 ,临床应用此温度下的灌注性热化疗是安全的
Objective To study the change of various indexes of liver function after perfusion hyperthermia with 60 ℃ perfused fluid through the hepatic artery to provide safety data for clinical perfusion thermochemotherapy.Methods The hepatic artery (n = 10) ℃ physiological saline 200min, 30min irrigation finished before perfusion and 1, 3, 5, 7d after perfusion to check the dynamic changes of liver function.Results DSA showed hepatic artery dilatation, delayed development of hepatic parenchyma; ALT, AST began to increase after ALT (10-fold ALT, 3-fold AST), then recovered gradually, all returned to normal after 1wk, while there was no significant change of bilirubin, albumin and γ-GT.Conclusion: ℃ interventional hyperthermia mild damage to the liver, clinical application of perfusion thermochemotherapy at this temperature is safe