A facile approach to tricyclo[6.4.0.0~(4,9)]-dodecane framework

• 作 者: Dong Wang William E.Crowe
• 机 构: Longwood Biopharmaceuticals,Inc.,Tianjin International Joint.Academy of Biomedicine,Department of Ch
• 出 处: Chinese Chemical Letters
• 发表日期: 2015年02期
• 关键词: facile innovative intramolecular steps alcohol filtered iodide silica removed cr

The unusual tricyclo[6.4.0.0~(4.9)]dodecane framework was constructed in eight linear steps in 13%overall yield.An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed.The key steps involve a Robinson annulation,a base induced decarboxylation and epimerization in a single step,and an intramolecular alkylation.

The unusual tricyclo [6.4.0.0 ~ (4.9)] dodecane framework was constructed in eight linear steps in 13% overall yield. An innovative strategy accessing the framework from bicyclo [3.3.1] nonanes was employed. The key steps involve a Robinson annulation , a base induced decarboxylation and epimerization in a single step, and an intramolecular alkylation.