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目的探讨戊乙奎醚对严重感染与感染性休克患者的治疗作用。方法符合严重感染与感染性休克诊断标准的ICU住院患者58例,随机分为两组,每组29例。除常规抗休克治疗外,A组另外肌注戊乙奎醚,首剂4～6mg,然后每8h重复给予2mg维持;B组另外静注654-2,首剂10～20mg,然后每15～30min重复同量维持。动态监测给药前后血流动力学、组织灌注指标及细胞因子变化。结果两组微循环均有明显改善。A组给药次数少,不增加心率。结论戊乙奎醚和654-2皆可明显改善严重感染与感染性休克患者微循环。戊乙奎醚给药次数少,使用方便,不增加心率,优于654-2。
Objective To investigate the therapeutic effect of penehyclidine on patients with severe infection and septic shock. Methods Fifty-eight ICU inpatients who met the diagnostic criteria of severe infection and septic shock were randomly divided into two groups (n = 29 in each group). In addition to conventional anti-shock treatment, A group of other intramuscular injection of penehyclidine, the first dose of 4 ~ 6mg, and then repeated every 8h to give 2mg maintenance; B additional intravenous injection of 654-2, the first dose of 10 ~ 20mg, and then every 15 ~ 30min repeat the same amount of maintenance. Dynamic monitoring before and after administration of hemodynamics, tissue perfusion index and cytokine changes. Results Both groups had significant improvement in microcirculation. Group A administration less, do not increase heart rate. Conclusion Penehyclidine and 654-2 can significantly improve microcirculation in patients with severe infection and septic shock. Penehyclidine administration less, easy to use, do not increase the heart rate, better than 654-2.