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背景与目的:原发性肝细胞癌(primaryhepatocellularcarcinoma,PHC)患者70%～90%伴有肝硬化、脾功能亢进以致患者术前外周血象偏低或术后外周血象恢复缓慢常影响经肝动脉化疗栓塞(transcatheterhepaticarterialchemoembolization,TACE)的正常进行。本研究探讨脾动脉部分栓塞(partialsplenicembolization,PSE)联合经TACE治疗合并脾功能亢进的PHC的方法和意义。方法:对26例PHC患者采用PSE联合TACE治疗的方法,26例PHC患者单用TACE治疗。结果:PSE联合TACE较单用TACE治疗明显改善PHC患者外周血象,PSE术后3天、1周、2周及4周外周血白细胞、红细胞、血小板较栓塞前明显提高。结论:PSE联合TACE是PHC合并脾亢的安全、有效治疗方法。
BACKGROUND & OBJECTIVE: Seventy to ninety percent of patients with primary hepatocellular carcinoma (PHC) have cirrhosis and hypersplenism, which leads to the low preoperative peripheral blood picture or the slow recovery of postoperative peripheral blood picture, often affecting hepatic artery chemotherapy Embolism (transcatheterheaticarterialchemoembolization, TACE) of the normal. This study was to explore the method and significance of partialsplenicembolization (PSE) combined with TACE in the treatment of PHC complicated with hypersplenism. Methods: 26 patients with PHC treated with PSE combined with TACE, 26 patients with PHC treated with TACE alone. Results: Peripheral blood of PHC patients was significantly improved by PSE combined with TACE and TACE alone. Peripheral blood leucocytes, erythrocytes and platelets at 3 days, 1 week, 2 weeks and 4 weeks after PSE were significantly higher than those before embolization. Conclusion: PSE combined with TACE is a safe and effective treatment for PHC combined with hypersplenism.