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作者使用单剂量消炎痛(indomethacin)口服,观察其对充血性心力衰竭病人肾功能的影响,并分析肾小球滤过率(GFR)与肾血浆流量(RPF)两者之间的关系。病人和方法严重左室功能失调患者25例(男18例、女7),年龄26～74(平均59±14)岁。其中缺血性心脏病8例。扩张型心肌病17例;心功能Ⅲ级者19例,Ⅳ级者6例(NYHA 分类)。所有病例的左室射血分数为9%～38%(平均22±8%)。血清肌酐<3.5mg/dl,平均血浆肾素活性(PRA)明显增加(3.6±3.8ng/ml/h)。全部病人正在服用洋地黄和利尿剂,病情相
The authors used a single dose of indomethacin orally to observe their effects on renal function in patients with congestive heart failure and to analyze the relationship between glomerular filtration rate (GFR) and renal plasma flow (RPF). Twenty-five patients (18 males and 7 females) with severe left ventricular dysfunction and age ranged from 26 to 74 (mean 59 ± 14) years. Including ischemic heart disease in 8 cases. Dilated cardiomyopathy in 17 cases; 19 cases of cardiac function in grade Ⅲ, Ⅳ in 6 cases (NYHA classification). Left ventricular ejection fraction was 9% to 38% (mean 22 ± 8%) in all cases. Serum creatinine <3.5mg / dl, mean plasma renin activity (PRA) was significantly increased (3.6 ± 3.8ng / ml / h). All patients are taking digitalis and diuretics, the disease phase