论文部分内容阅读
目的 :探讨心钠素 (ANP)在新生儿窒息中的作用及同时检测肌酸激酶同工酶MB(CK -MB)的临床意义。方法 :应用放射免疫法检测 48例窒息新生儿生后 2天、7天血浆ANP的含量 ,同时检测CK -MB的含量 ,并与 2 0例足月健康儿对照。结果 :(1)ANP水平轻度窒息组高于正常对照组 ,重度窒息组高于轻度窒息组 ,均有显著性差异 ;随着窒息与缺氧的好转 ,ANP逐渐下降 ;(2 )CK -MB与窒息程度呈正相关 ,各组间差异显著 ;(3)ANP与CK -MB二者关系 ,在轻度窒息组正相关无意义 ,在重度窒息组正相关意义显著。结论 :ANP参与了窒息时生理病理调节 ,同时测定ANP及CK -MB是估计病情及预后的客观指标。并有利于治疗 ,改善预后。
Objective: To investigate the role of atrial natriuretic peptide (ANP) in neonatal asphyxia and the clinical significance of simultaneous detection of creatine kinase MB (CK-MB). Methods: The levels of plasma ANP in 48 neonates with asphyxia at 2 and 7 days after birth were measured by radioimmunoassay. The levels of CK-MB were detected simultaneously with 20 healthy children. Results: (1) The levels of ANP in mild asphyxia group were higher than those in normal control group, severe asphyxia group was higher than those in mild asphyxia group, and there was significant difference; ANP decreased with asphyxia and hypoxia; (2) CK -MB was positively correlated with the degree of asphyxia, and there was significant difference among the groups. (3) The relationship between ANP and CK-MB was not significant in mild asphyxia group and significant in severe asphyxia group. Conclusion: ANP is involved in the regulation of physiological and pathological changes during asphyxia, and the determination of ANP and CK-MB is an objective indicator of disease progression and prognosis. And is conducive to treatment, improve prognosis.