六对甲苯磺酸甘露醇酯的合成

• 作 者: 詹天荣 宋金明
• 机 构: 中国科学院海洋研究所海洋生态与环境科学重点实验室,中国科学院海洋研究所海洋生态与环境科学重点实验室 青岛266071,中国科学院研究生院北京100039,青岛266071
• 出 处: 化学通报
• 发表日期: 2003年09期
• 关键词: D-甘露醇 对甲苯磺酰氯 合成

首次以甘露醇和对甲苯磺酰氯为原料 ,合成了六对甲苯磺酸甘露醇酯 ,讨论了多种因素对酯化反应收率的影响 ,并对其结构进行了确定。结果表明 ,获得六对甲苯磺酸甘露醇酯最佳的反应条件为 :以 1 0 0mL吡啶为溶剂兼催化剂 ,对甲苯磺酰氯与D 甘露醇的摩尔比为 0 3 1 5∶0 0 5 0 ,反应时间为 4h ,反应温度为 0～ 1 0℃ ,收率可达 85 4%。

For the first time, mannitol and p-toluenesulfonyl chloride were used as raw materials to synthesize mannitol hexa-p-toluenesulfonate. The effects of various factors on the yield of esterification reaction were discussed and their structures were determined. The results showed that the optimal reaction conditions for obtaining mannitol hexa-p-toluenesulfonate were as follows: the molar ratio of p-toluenesulfonyl chloride to D-mannitol was 0 3 1 5:0 0 5 0 with 100 mL of pyridine as solvent and catalyst , The reaction time is 4h, the reaction temperature is 0 ~ 10 ℃, the yield can reach 85 4%.