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目的 :观察杏丁注射液治疗缺血性中风的疗效及对血浆超氧化物歧化酶 (SOD)、丙二醛 (MDA)、过氧化脂质 (LPO)的影响。方法 :87例患者按随机单盲原则分为杏丁注射液治疗组 (n =5 8)和复方丹参注射液对照组(n =2 9) ,15d为 1个疗程。测定治疗前后神经功能缺损积分 ,生活能力状态和血浆SOD、MDA和LPO水平。结果 :与对照组比较 ,治疗组缺血性中风的临床疗效及神经功能缺损积分的减少有明显差异 (P <0 .0 5 ) ,血浆SOD水平升高 ,MDA和LPO水平降低。结论 :杏丁注射液治疗缺血性中风安全有效 ,其机制可能与清除自由基有关。
Objective: To observe the therapeutic effect of Xingding Injection on ischemic stroke and its effects on plasma SOD, MDA and LPO. Methods: Eighty - seven patients were divided into Xingding injection group (n = 58) and compound Salvia miltiorrhiza injection group (n = 29) according to randomized single - blind principle. One course of treatment was 15 days. Neurological impairment scores, viability status and plasma levels of SOD, MDA and LPO were measured before and after treatment. Results: Compared with the control group, there was a significant difference in the clinical efficacy and the decrease of neurological deficit scores in the treatment group (P <0.05). The levels of plasma SOD and MDA and LPO decreased. Conclusion: Xingding injection is safe and effective in the treatment of ischemic stroke. Its mechanism may be related to the scavenging of free radicals.