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目的:探讨急性冠状动脉综合症(acute coronary syndromes,ACS)患者血浆溶血磷脂酸(1ysophosphatidic acid,LPA)及基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平的变化,探讨其在ACS中可能的临床意义。方法:入选100例ACS患者,根据病情将其分为急性心肌梗死(AMI)组50例,不稳定型心绞痛(UAP)组50例,并入选40例健康者作为对照组,分别用无机磷定量法和酶联免疫吸附测定法测定血浆LPA、MMP-9水平。结果:AMI组血浆LPA、MMP-9水平显著高于UAP组(LPA:3.29±0.42vs2.67±0.37;MMP-9:481.7±86.5vs237.85±65.34,P<0.01)并且两组均显著高于对照组(LPA:1.82±0.31;MMP-9:87.42±23.85P<0.01);LPA与MMP-9水平呈正相关(r=0.224,P<0.05)。结论:LPA与MMP-9可能是提示不稳定斑块的形成、破裂,进而导致急性冠状动脉综合征的危险信号。
Objective: To investigate the changes of plasma lysophosphatidic acid (LPA) and matrix metalloproteinase-9 (MMP-9) levels in patients with acute coronary syndromes (ACS) In the possible clinical significance. Methods: A total of 100 patients with ACS were enrolled and divided into 50 cases of AMI group and 50 cases of unstable angina pectoris group (UAP group) according to their condition. Forty healthy subjects were selected as control group, Plasma and LPA, MMP-9 levels were measured by ELISA and enzyme-linked immunosorbent assay. Results: The levels of plasma LPA and MMP-9 in AMI group were significantly higher than those in UAP group (LPA: 3.29 ± 0.42 vs 2.67 ± 0.37; MMP-9: 481.7 ± 86.5 vs 237.85 ± 65.34, P <0.01) (LPA: 1.82 ± 0.31; MMP-9: 87.42 ± 23.85 P <0.01). There was a positive correlation between LPA and MMP-9 (r = 0.224, P <0.05). Conclusions: LPA and MMP-9 may be risk signals for the formation of unstable plaque, rupture and then acute coronary syndrome.