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双唑草腈(Pyracloni)属原卟啉原氧化酶抑制剂[1],主要作用于水稻田除草用。其作用机制是通过植物神经中元卟啉原氧化酶积累而发挥药效[2]。为了解双唑草腈原药的毒性效应以及可能靶器官,该研究对双唑草腈原药进行了大鼠亚慢性经口毒性试验,求出其亚慢性经口染毒的最大无作用剂量,为其进行长期毒性试验提供毒理学依据。1材料和方法1.1受试物双唑草腈原药,淡黄色粉末,纯度为
Pyracloni (Pyracloni) is a protoporphyrinogen oxidase inhibitor [1], the main role in the paddy field weeding. Its mechanism of action is through the autoporphyrinogen oxidase accumulation and play a pharmacodynamic effect [2]. In order to understand the toxicity effect of the azole oxalicotine and the possible target organ, this study conducted a sub-chronic oral toxicity test on the azadirachtin in rats to determine the maximum non-acting dose of sub-chronic oral administration , For its long-term toxicity test to provide toxicological basis. 1 Materials and methods 1.1 test substance oxazole nitrile original drug, light yellow powder, purity