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多年以来的研究,关于SiO2粉尘致肺纤维化机理的研究有了一定的进展[1,2]。SiO2粉尘对以肺泡巨噬细胞(AM)膜为主的生物膜的损伤,是矽肺发病的重要起因。许多研究表明,矽肺发病中的自由基对生物膜呈现广泛的损伤,导致细胞膜破碎,最终引起细胞死亡。一...
Over the years, there has been some progress in the research on the mechanism of SiO2-induced pulmonary fibrosis [1,2]. SiO2 dust on alveolar macrophages (AM) membrane-based biofilm damage is an important cause of silicosis. Many studies show that free radicals in silicosis exhibit extensive damage to the biofilm, resulting in disruption of the cell membrane and eventually cell death. one...