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目的研究bcl-2蛋白在舌鳞癌中的表达及其与临床病理因素的关系。方法应用免疫细胞化学法检测舌癌Tca-8113细胞株bcl-2蛋白的表达;应用免疫组织化学法检测bcl-2蛋白在60例舌鳞癌组织中的表达情况。结果舌癌细胞株中bcl-2阳性表达,bcl-2在舌鳞癌中阳性表达率为53.3%(32/60)其阳性表达在有无淋巴结转移、病理分化等方面差异有显著性(P<0.05)。结论bcl-2基因与舌鳞癌的自然发展过程有关,可能会成为舌癌新的诊断标志物基因治疗靶点。
Objective To study the expression of bcl-2 protein in tongue squamous cell carcinoma and its relationship with clinicopathological factors. Methods The expression of bcl-2 protein in tongue cancer Tca-8113 cell line was detected by immunocytochemistry. The expression of bcl-2 protein in 60 cases of tongue squamous cell carcinoma was detected by immunohistochemistry. Results The positive rate of bcl-2 expression in tongue cancer cell lines was 53.3% (32/60) in tongue squamous cell carcinoma, and the positive rate of bcl-2 was significantly different between lymph node metastasis and pathological differentiation <0.05). Conclusion The bcl-2 gene is related to the natural process of tongue squamous cell carcinoma and may be a new therapeutic target for gene therapy of tongue cancer.