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目的:制备藏药砂生槐子总生物碱的生物黏附迷你肠溶片,以期达到增加药物在肠道的滞留时间和缓释的目的.方法:通过前期单因素考察确定对溶出率影响较大的因素,以L9(33)正交试验确定3 mm迷你片芯的最优处方,并对其进行肠溶包衣.评价迷你片芯的生物黏附力和体外溶性行为,采用小动物活体成像技术考察制剂在动物体内的滞留情况.结果:片芯的最佳处方为含药淀粉与黏附材料之比为5∶1,填充剂为PVP,海藻酸钠与卡波姆934的比例为2∶1,肠溶迷你片的溶出试验表明累计释放率达到80％以上.体内外生物黏附性实验证明其具有一定的生物黏附力.结论:生物黏附迷你肠溶片在胃肠道能够有效滞留且累计释放率较好,达到了实验设计的预期目标,为藏药砂生槐子总生物碱肠溶片的制备以及生物黏附片的制备提供了一定的参考价值.“,”Objective: To prepare biological adhesive enteric-coated mini tablets for the extraction of sophora moorcroftiana seed in order to increase the retention time and release time of the drug in the intestine. Methods: The dissolution rate of the influence factors was determined through thesingle factor test, then L9(33) used to determine the optimal formulation by orthogonal test. The 3 mm mini core was prepared with the best prescription, and the core was coated with enteric coating. The bioadhesive force of mini core was investigated by self-made adhesion apparatus, and the small animal live imaging technique was used to investigate the retention of the preparations in animals. Results: The best prescription of tablet core is that containing starch and adhesive material ratio was 5∶1, and that the filler is sucrose; The sodium alginate and Carbopol 934 as the proportion of 2∶1, and enteric mini tablet dissolution test showed that the drug release in simulated gastric juice, the cumulative release rate reached above 80％. The core is adhesion in the intestinal tract, showing a small animal in vivo fluorescence imaging technology with the adhesion of enteric mini tablets in vivo. Conclusion: Mini enteric tablets can effectively and the cumulative release rate of good retention in the gastrointestinal tract, to achieve the expected goal of experimental design, as in Tibetan medicine enteric coated tablets and preparation of bioadhesive tablets preparation provides an important reference value.