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目的探讨CO_2激光联合低温等离子射频消融术治疗累及前联合早期声门型喉癌的疗效。方法选取2012年3月至2015年7月间南京医科大学第一附属医院和徐州医科大学附属淮安医院收治的70例累及前联合早期声门型喉癌患者,观察组采用CO_2激光联合低温等离子射频消融术(30例)治疗,对照组采用CO_2激光(40例)治疗。对比两组患者嗓音障碍情况及术后复发率。结果术后3个月,两组患者嗓音障碍指数量表(VHI)等级分布比较,差异无统计学意义(P>0.05);观察组患者复发率为6.7%,对照组为25.0%,两组比较,差异有统计学意义(P<0.05)。结论 CO_2激光联合低温等离子射频消融术治疗累及前联合早期声门型喉癌疗效确切,对病变暴露困难者更有优势,喉部结构和喉功能保全良好。
Objective To investigate the efficacy of CO_2 laser combined with low temperature plasma radio frequency ablation in the treatment of pre-involvement and early glottic laryngeal cancer. Methods From March 2012 to July 2015, 70 patients with pre-combined early glottic laryngeal cancer admitted to the First Affiliated Hospital of Nanjing Medical University and Huai’an Hospital Affiliated to Xuzhou Medical University were selected. The observation group was treated with CO_2 laser combined with low-temperature plasma radio frequency Ablation (30 cases) treatment, the control group using CO_2 laser (40 cases) treatment. The two groups of patients with voice disorders and postoperative recurrence rate. Results There was no significant difference in grade distribution of VHI between the two groups (P> 0.05) at 3 months after operation. The recurrence rate was 6.7% in the observation group and 25.0% in the control group The difference was statistically significant (P <0.05). Conclusions CO_2 laser combined with low temperature plasma radiofrequency ablation is effective in treating pre-operative combined with early glottic laryngeal cancer. It is more effective in patients with pathological changes, and laryngeal structure and laryngeal function are well preserved.