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目的 :探讨不同剂型人用狂犬病疫苗的不良反应和免疫效果。方法 :选取2015年5月--2016年5月期间在本院门诊接受狂犬病疫苗注射的100例患者,根据计算机随机分组法分为研究组(n=50)和对照组(n=50),对照组应用辽宁成大人用狂犬疫苗,研究组应用辽宁依生人用狂犬疫苗,比较两组患者的不良反应和免疫效果。结果 :两组患者不良反应情况比较,研究组总发生例数为3例(6.00%),对照组总发生例数为10例(20.00%),研究组总发生例数明显少于对照组(P<0.05);两组患者抗体阳性转化情况比较,研究组总转化例数为49例(98.00%),对照组总转化例数为40例(80.00%),研究组总转化例数明显多于对照组(P<0.05)。结论:辽宁依生人用狂犬疫苗不良反应较少、抗体阳性转化率更高,明显优于辽宁成大人用狂犬疫苗,可见辽宁依生人用狂犬疫苗有助于提高患者的预防效果,能提高患者的生命质量,具有较高的临床应用价值,建议临床进一步推广。
Objective: To investigate the adverse reactions and immunological effects of rabies vaccine of different dosage forms. Methods: A total of 100 patients admitted to our hospital from May 2015 to May 2016 with rabies vaccination were divided into study group (n = 50) and control group (n = 50) according to computerized randomization method. Liaoning rabies vaccine for adults was applied in the control group. Liaoning rabies vaccine was used in the study group to compare the adverse reactions and immune effects of the two groups. Results: There were 3 cases (6.00%) in the study group and 10 cases (20.00%) in the control group. The total number of cases in the study group was significantly less than that in the control group P <0.05). The positive conversion rate of antibody in the two groups was 49 cases (98.00%) in the study group, 40 cases (80.00%) in the control group, and the total number of cases in the study group was significantly higher In the control group (P <0.05). Conclusion: There are few side effects in Liaoning rabies vaccine and the antibody positive conversion rate is higher than that of Liaoning rabies vaccine, which shows that Liaoning rabies vaccine can help to improve the preventive effect and increase The quality of life of patients with high clinical value, it is recommended to further promote the clinical.