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目的探析硝苯地平控释片联合倍他乐克治疗原发性高血压的临床疗效。方法将100例渭南市妇幼保健院住院部收治的原发性高血压患者按随机频数表均分为观察组和对照组各50例,观察组以硝苯地平控释片和倍他乐克治疗,对照组只以硝苯地平控释片处理,治疗前后均对两组患者的24 h动态血压、心率及不良反应详细记录,连续治疗8周后,对比各项指标的变化分析治疗效果及安全性。结果治疗后两组患者24 h收缩压、舒张压和心率均明显下降,与治疗前比较差异显著(P<0.05)。治疗后,观察组24 h收缩压、舒张压和心率均明显低于对照组,差异显著(P<0.05)。观察组收缩压和舒张压的谷峰比均明显高于对照组,差异显著(P<0.05),表明观察组血压控制更平稳。连续治疗8周后,观察组总有效率为96.0%,对照组总有效率为78.0%,两组比较差异有统计学意义(P<0.05)。观察组不良反应率8%明显低于对照组的22%,两组比较差异有统计学意义(P<0.05)。结论硝苯地平控释片联合倍他乐克治疗原发性高血压不仅有效,而且大大降低了药物的副作用,是临床的合理选择。
Objective To investigate the clinical efficacy of nifedipine GITS in combination with metoprolol in the treatment of essential hypertension. Methods A total of 100 cases of primary hypertension admitted to Inpatient Department of Weinan MCH hospital were divided into observation group and control group according to random frequency table. The observation group was treated with nifedipine controlled release tablets and metoprolol . The control group was treated with nifedipine controlled release tablets only. The 24-hour ambulatory blood pressure, heart rate and adverse reactions of both groups were recorded before and after treatment. After 8 weeks of continuous treatment, the changes of each index were compared to analyze the therapeutic effect and safety Sex. Results After treatment, the systolic blood pressure, diastolic blood pressure and heart rate of both groups decreased significantly at 24 h, which were significantly different from those before treatment (P <0.05). After treatment, systolic blood pressure, diastolic blood pressure and heart rate in observation group at 24 h were significantly lower than those in control group (P <0.05). The peak-to-peak systolic and diastolic blood pressures in the observation group were significantly higher than those in the control group (P <0.05), indicating that blood pressure was controlled more smoothly in the observation group. After continuous treatment for 8 weeks, the total effective rate was 96.0% in the observation group and 78.0% in the control group. The difference between the two groups was statistically significant (P <0.05). The rate of adverse reactions in the observation group was significantly lower than 8% in the control group (8%), the difference between the two groups was statistically significant (P <0.05). Conclusion Nifedipine controlled release tablets combined with Betaloc therapy is not only effective in treating essential hypertension, but also greatly reduces side effects of drugs, which is a reasonable clinical choice.