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目的研究辛伐他汀对冠心病不稳定型心绞痛患者血脂、心电、临床症状的影响。方法66例冠心病不稳定型心绞痛患者随机分为常规治疗组和辛伐他汀治疗组,观察治疗2个月心绞痛患者的血脂,心电图及临床症状的变化。结果治疗2个月时辛伐他汀组便出现总胆固醇(total cholesterol,TC),甘油三脂(triglycerides,TG)低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)下降,高密度脂蛋白胆固醇(high-densitylipoproteincholesterol,HDL-C)升高,辛伐他汀治疗组心绞痛症状缓解率明显提高,心电图缺血明显改善。结论辛伐他汀降脂疗效显著,对不稳定型心绞痛有明显缓解作用。
Objective To study the effects of simvastatin on blood lipids, ECG and clinical symptoms in patients with coronary heart disease and unstable angina pectoris. Methods Sixty-six patients with unstable angina pectoris were randomly divided into routine treatment group and simvastatin treatment group. The changes of blood lipid, electrocardiogram and clinical symptoms in patients with angina pectoris at 2 months were observed. Results Total cholesterol (TC), low triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein High-density lipoprotein cholesterol (HDL-C) increased, the remission rate of angina pectoris in simvastatin group was significantly increased, and ischemic electrocardiogram was significantly improved. Conclusion Simvastatin has a significant effect on lipid lowering and relieves unstable angina pectoris.