褶合光谱法测定复方地塞米松滴眼液的含量

• 作 者: 史德懿 刘怡 张冬春
• 机 构: 上海市第六人民医院,上海医科大学药学院,第二军医大学药学院
• 出 处: 药学实践杂志
• 发表日期: 1999年01期
• 关键词: 褶合光谱法 地塞米松磷酸钠 地塞米松滴眼液 尼泊金乙酯 组分测定 褶合光谱仪 紫外分光光度法 常规分析 差示分光光度法 标示量

目的：建立不经分离同时测定地塞米松磷酸钠及干扰组分尼泊金乙酯含量的测定方法。方法：以蒸馏水为空白，采用褶合光谱法。结果：平均回收率为１００８％，９９３９％；ＲＳＤ为１００％，０６１％。结论：本法方便准确，适用于紫外吸收有干扰的多组分制剂的常规分析。

OBJECTIVE: To establish a method for simultaneous determination of dexamethasone sodium phosphate and interfering component ethylparaben without separation. Methods: Distilled water was blank, and the convolutional spectrometry was used. Results: The average recoveries were 1008% and 9939%. The RSDs were 100% and 061% respectively. Conclusion: This method is convenient and accurate and is suitable for the routine analysis of multi-component preparations that interfere with UV absorption.