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目的 :测定汉防己甲素在体内样品中的浓度 ,研究汉防己甲素经微囊化后的体内分布特点。方法 :建立生物样品中汉防己甲素浓度测定的RP HPLC法 ,对比汉防己甲素水针剂和微囊混悬液经小鼠尾静脉注射后 ,不同时间时汉防己甲素的浓度值 ,分析药物的肺靶向性。结果 :生物样品检测方法简便易行 ,结果准确 ,微囊化汉防己甲素在肺中的浓度明显提高 ,且缓慢降低 ,具有明显的肺靶向性。结论 :汉防己甲素经微囊化后 ,可浓集于肺部 ,且具有缓慢释放的特点 ,对肺动脉高压的防治具有重要意义。
OBJECTIVE: To determine the concentration of tetrandrine in the in vivo samples and to study the distribution of tetrandrine in the body after microencapsulation. Methods: RP HPLC method was established to determine the concentration of tetrandrine in biological samples. The concentration of tetrandrine at different time after injection of tetrandrine water and microcapsule suspension were compared. Lung targeting of drugs. Results: The bioassay method was simple and accurate, and the results were accurate. The concentration of microencapsulated tetrandrine in lung significantly increased and slowly decreased with obvious lung targeting. CONCLUSION: Tetrandrine can be concentrated in the lung after microencapsulation, and has the characteristics of slow release. It is of great significance for the prevention and treatment of pulmonary hypertension.